Podiatry
Podiatry is a branch of health care devoted to the study, diagnosis, and treatment of disorders of the foot, ankle and lower leg.
We work very closely with podiatrists to compound individualized medications tailored to your needs including the following:
The following are some case reports and studies in support of some of the compounds we provide for podiatry. More information regarding methods used is available upon request. The strengths and ingredients can be adjusted according to the physicians' and patients' needs:
Objectives:
A topical solution of cantharidin, podophyllotoxin, and salicylic acid was found to be safe and effective in the treatment of simple and mosaic plantar warts (Am Podiatr Med Assoc. 2008 Nov-Dec;98(6):445-50).
Results:
After 6 months of follow-up, complete eradication of the plantar warts was noted in 138 of the 144 patinets (95.8%). Of these patients, 125 (86.8%) required a single application of the solution, and 13 (9.0%) needed two or more applications. No significant adverse effects or complications were observed.
Conclusion:
A topical solution of cantharidin, podophyllotoxin, and salicylic acid was found to be safe and effective in the treatment of simple and mosaic plantar warts. This formulation is a promising alternative treatment modality for plantar warts.
Terbinafine/Itraconazole/Ketoconazole/Clotrimazole/Undecylenic acid in Tea Tree Oil/DMSO for Onychomycosis
Failure to respond to conventional therapy and relapse rates of approximately 25% to 50% both point to the need for a shift in the approach to treating this chronic disease.
In vitro data indicate synergistic and additive effects when combining certain antifungal agents, eg, ciclopirox and terbinafine. Drug penetration to different parts of the nail unit and complimentary modes of action may contribute to the success of combination therapy. PMID: 15287394
Benzoic Acid 6%/Salicylic Acid 3% Topical ointment for Heel Fissures
There is a very good prescription medication for reducing the callused area called Whitfield's Ointment. this is an old time remedy that many pharmacies no longer carry. With a prescription, we will make up the medication for you. the medication contains mild acid compounds that reduce the thick callus. Care should be used with this medication and it should only be used under the supervision of a doctor. (podiatrynetwork.com)
Phenytoin/Misoprostol Topical Gel for Ulcer/Wound Healing
Objectives:
The methodological quality of several papers on the effects of topical phenytoin on wound healing was assessed in a systematic review using the van Tulder method and in addition best evidence synthesis was carried out. The magnitude of the effect of phenytoin therapy in the studies included in the systematic review was investigated in four of the 14 trials.
Results:
There was moderate evidence presented to support the use of phenytoin for the treatment of leg ulcers, leprosy wounds, chronic wounds and diabetic foot ulcers. There was a positive percentage treatment effect in favor of the phenytoin-treated group in one study investigating diabetic foot wounds and one study on chronic wounds.
Conclusion:
Overall it would appear that studies investigating the effect of topical phenytoin on wound healiing are of moderate methodological quality, and these suggest that there may be a positive effect on wound healing in a variety of wounds. PMID: 17854378
Acetic Acid 5% Iontophoresis Solution for Plantar Fasciitis
Objectives:
To determine if, in the short term, acetic acid and dexamethasone iontophoresis combined with LowDye taping are effective in treating the symptoms of plantar fasciitis.
Results:
Data for 42 feet from 31 subjects were used in the study. After the treatment phase, all groups showed significant improvements in morning pain, average pain, and morning stiffness. However for morning pain, the acetic acid/taping group showed a significantly greater improvement than the dexamethasone/taping intervention. Only acetic acid maintained treatment effect for stiffness symptoms compared with placebo (p=0.031) and dexamethasone at follow up.
Conclusion:
Six treatments of acetic acid iontophoresis combined with taping gave greater relief from stiffness symptoms than, and equivalent relief from pain symptoms to, treatment with dexamethasone/taping. for the best clinical results at four weeks, taping combined with acetic acid is the preferred treatment option compared with taping combined with dexamethasone or saline iontophoresis.PMID:16488901
L-Arginine HCl 12.5% Transdermal Cream for Diabetes and Foot Complications
Objectives:
To determine whether supplying L-arginine transdermally would improve vascular function of the feet in patients with diabetes as indicated by flow and temperature.
Conclusion:
Treatment of the feet with a transdermal preparation of L-arginine improved both flow and temperature, and this effect was surprisingly long lasting. Such improvement of compromised local blood flow should be beneficial and could reduce the complications of Diabetes (Diabetes Care.2004 Jan;27(1):284-5).
Glyceryl Trinitrate 0.2% Topical Ointment for Achilles Tendinopathy
Objectives:
This treatment has demonstrated short-term efficacy in chronic noninsertional Achilles tendinopathy. No long-term follow up is reported. We aimed to assess if the demonstrated efficacy of this treatment persisted 3 years after discontinuation of therapy.
Results:
Patients treated with topical glyceryl trinitrate had significantly less Achilles tendon tenderness (p=0.03), and improved VISA-A scores (p=0.04) than those in the placebo group; 88% (28 of 32 tendons) of patients were completely asymptomatic at 3 years (VISA-A score of 100) compared to 67% (24 or 36 tendons) of patients treated with rehabilitation alone (p=0.03 with CHi square analysis).
Conclusion:
Topical glyceryl trinitrate treatment has demonstrated efficacy in treating chronic noninsertional Achilles tendinopathy, and the treatment benefits continue at 3 years. This suggests that the mechanism of action of topical glyceryl trinitrate on chronic tendinopathies is more than an analgesic effect. PMID: 17923056
We work very closely with podiatrists to compound individualized medications tailored to your needs including the following:
- Inflammation
- Diabetic Neuropathy
- Neuropathic Sprains
- Arthritis
- Onychomycosis
- Heel Fissures
- Ulcers
- Wound Healing
- Chronic pain and inflammation
- Plantar Warts
The following are some case reports and studies in support of some of the compounds we provide for podiatry. More information regarding methods used is available upon request. The strengths and ingredients can be adjusted according to the physicians' and patients' needs:
Objectives:
A topical solution of cantharidin, podophyllotoxin, and salicylic acid was found to be safe and effective in the treatment of simple and mosaic plantar warts (Am Podiatr Med Assoc. 2008 Nov-Dec;98(6):445-50).
Results:
After 6 months of follow-up, complete eradication of the plantar warts was noted in 138 of the 144 patinets (95.8%). Of these patients, 125 (86.8%) required a single application of the solution, and 13 (9.0%) needed two or more applications. No significant adverse effects or complications were observed.
Conclusion:
A topical solution of cantharidin, podophyllotoxin, and salicylic acid was found to be safe and effective in the treatment of simple and mosaic plantar warts. This formulation is a promising alternative treatment modality for plantar warts.
Terbinafine/Itraconazole/Ketoconazole/Clotrimazole/Undecylenic acid in Tea Tree Oil/DMSO for Onychomycosis
Failure to respond to conventional therapy and relapse rates of approximately 25% to 50% both point to the need for a shift in the approach to treating this chronic disease.
In vitro data indicate synergistic and additive effects when combining certain antifungal agents, eg, ciclopirox and terbinafine. Drug penetration to different parts of the nail unit and complimentary modes of action may contribute to the success of combination therapy. PMID: 15287394
Benzoic Acid 6%/Salicylic Acid 3% Topical ointment for Heel Fissures
There is a very good prescription medication for reducing the callused area called Whitfield's Ointment. this is an old time remedy that many pharmacies no longer carry. With a prescription, we will make up the medication for you. the medication contains mild acid compounds that reduce the thick callus. Care should be used with this medication and it should only be used under the supervision of a doctor. (podiatrynetwork.com)
Phenytoin/Misoprostol Topical Gel for Ulcer/Wound Healing
Objectives:
The methodological quality of several papers on the effects of topical phenytoin on wound healing was assessed in a systematic review using the van Tulder method and in addition best evidence synthesis was carried out. The magnitude of the effect of phenytoin therapy in the studies included in the systematic review was investigated in four of the 14 trials.
Results:
There was moderate evidence presented to support the use of phenytoin for the treatment of leg ulcers, leprosy wounds, chronic wounds and diabetic foot ulcers. There was a positive percentage treatment effect in favor of the phenytoin-treated group in one study investigating diabetic foot wounds and one study on chronic wounds.
Conclusion:
Overall it would appear that studies investigating the effect of topical phenytoin on wound healiing are of moderate methodological quality, and these suggest that there may be a positive effect on wound healing in a variety of wounds. PMID: 17854378
Acetic Acid 5% Iontophoresis Solution for Plantar Fasciitis
Objectives:
To determine if, in the short term, acetic acid and dexamethasone iontophoresis combined with LowDye taping are effective in treating the symptoms of plantar fasciitis.
Results:
Data for 42 feet from 31 subjects were used in the study. After the treatment phase, all groups showed significant improvements in morning pain, average pain, and morning stiffness. However for morning pain, the acetic acid/taping group showed a significantly greater improvement than the dexamethasone/taping intervention. Only acetic acid maintained treatment effect for stiffness symptoms compared with placebo (p=0.031) and dexamethasone at follow up.
Conclusion:
Six treatments of acetic acid iontophoresis combined with taping gave greater relief from stiffness symptoms than, and equivalent relief from pain symptoms to, treatment with dexamethasone/taping. for the best clinical results at four weeks, taping combined with acetic acid is the preferred treatment option compared with taping combined with dexamethasone or saline iontophoresis.PMID:16488901
L-Arginine HCl 12.5% Transdermal Cream for Diabetes and Foot Complications
Objectives:
To determine whether supplying L-arginine transdermally would improve vascular function of the feet in patients with diabetes as indicated by flow and temperature.
Conclusion:
Treatment of the feet with a transdermal preparation of L-arginine improved both flow and temperature, and this effect was surprisingly long lasting. Such improvement of compromised local blood flow should be beneficial and could reduce the complications of Diabetes (Diabetes Care.2004 Jan;27(1):284-5).
Glyceryl Trinitrate 0.2% Topical Ointment for Achilles Tendinopathy
Objectives:
This treatment has demonstrated short-term efficacy in chronic noninsertional Achilles tendinopathy. No long-term follow up is reported. We aimed to assess if the demonstrated efficacy of this treatment persisted 3 years after discontinuation of therapy.
Results:
Patients treated with topical glyceryl trinitrate had significantly less Achilles tendon tenderness (p=0.03), and improved VISA-A scores (p=0.04) than those in the placebo group; 88% (28 of 32 tendons) of patients were completely asymptomatic at 3 years (VISA-A score of 100) compared to 67% (24 or 36 tendons) of patients treated with rehabilitation alone (p=0.03 with CHi square analysis).
Conclusion:
Topical glyceryl trinitrate treatment has demonstrated efficacy in treating chronic noninsertional Achilles tendinopathy, and the treatment benefits continue at 3 years. This suggests that the mechanism of action of topical glyceryl trinitrate on chronic tendinopathies is more than an analgesic effect. PMID: 17923056